grooming与精神状态文献
下述主要有急性应激、自闭症、压力模型中的抑郁、强迫症几种精神类疾病，普遍在疾病中grooming变多，也有少数文献报道了减少。
文献1：急性应激中grooming动作明显增多
不同实验组（急性应激组与正常对照组）的行为特征存在明显差异，动作谱可见grooming动作明显增多。
Ye J, Xu Y, Huang K, Wang X, Wang L, Wang F. Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors [published correction appears in Cell Rep. 2025 Jun 24;44(6):115803. doi: 10.1016/j.celrep.2025.115803.]. Cell Rep. 2025;44(2):115239. doi:10.1016/j.celrep.2025.115239
文献2：自闭症中grooming动作明显增多
分别采集对照组（WT，正常小鼠）和敲除组（KO，Shank3B基因敲除小鼠）三维行为视频数据，进行三维重建以及无监督的动作序列分解。发现KO组，自闭症中grooming动作明显增多
Huang K, Han Y, Chen K, et al. A hierarchical 3D-motion learning framework for animal spontaneous behavior mapping. Nat Commun. 2021;12(1):2784. Published 2021 May 13. doi:10.1038/s41467-021-22970-y
文献3：CRS中grooming动作明显变少（压力模型中的抑郁）
AI 精细自发行为分析揭示其自发行为存在共性与异质性变化；慢性天敌压力(CRS)模型组grooming动作明显减少
Tseng YT, Zhao B, Ding H, Liang L, Schaefke B, Wang L. Systematic evaluation of a predator stress model of depression in mice using a hierarchical 3D-motion learning framework. Transl Psychiatry. 2023;13(1):178. Published 2023 May 25. doi:10.1038/s41398-023-02481-8
文献4：CUMS中grooming明显变少
钩吻素对慢性不可预测应激诱导的抑郁小鼠的抗抑郁机制，CUMS中grooming明显变少
Liu EY, Yang CL, Tsai JC, Cheng HY, Peng WH. Antidepressive mechanisms of rhynchophylline in mice with chronic unpredictable stress-induced depression. J Ethnopharmacol. 2023;309:116302. doi:10.1016/j.jep.2023.116302
文献5：CRS中grooming时长变多
腹侧纹状体双向调控小鼠抑郁样行为的新环路机制：CRS中grooming时长变多
Zhang YF, Wu J, Wang Y, et al. Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice. Nat Commun. 2023;14(1):6887. Published 2023 Oct 28. doi:10.1038/s41467-023-42662-z；
文献6：强迫症中grooming时长变多
Brownstien M, Lazar M, Botvinnik A, et al. Striking long-term beneficial effects of single dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming. Mol Psychiatry. 2025;30(3):1172-1183. doi:10.1038/s41380-024-02786-0
文献7：强迫症中grooming变多
Soto JS, Neupane C, Kaur M, Pandey V, Wohlschlegel JA, Khakh BS. Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice. Neuron. 2024;112(20):3412-3423.e6. doi:10.1016/j.neuron.2024.07.019
文献8：强迫症中grooming时长次数变多
Piantadosi SC, Manning EE, Chamberlain BL, et al. Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior. Nat Commun. 2024;15(1):4434. Published 2024 May 24. doi:10.1038/s41467-024-48331-z
文献9：强迫症中grooming次数变多
Ramírez-Armenta KI, Alatriste-León H, Verma-Rodríguez AK, Llanos-Moreno A, Ramírez-Jarquín JO, Tecuapetla F. Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice. Neuropsychopharmacology. 2022;47(2):477-487. doi:10.1038/s41386-021-01161-9
文献10：强迫症中grooming时长变多
Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA. Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Nat Commun. 2021;12(1):6040. Published 2021 Oct 15. doi:10.1038/s41467-021-26247-2
文献11：grooming比例变少
spino的全身丢失减少了梳理的比例，梳理的次数（梳理频率）和单次梳理的平均持续时间（平均梳理持续时间）无变化。
Morris CW, Watkins DS, Shah NR, et al. Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming. Biol Psychiatry. 2023;93(11):976-988. doi:10.1016/j.biopsych.2022.12.008